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Category Archives: Biotechnology

Replacing the Top Banana

11 Thursday Jan 2018

Posted by Nuetzel in Agriculture, Biotechnology

≈ Leave a comment

Tags

Apple Banana, Applied Mythology, Bananas.org, Berry Banana, Cavendish Banana, Dessert Bananas, genetic engineering, GMO Papaya, GMOs, Gros Michel Banana, Monoculture, Panama Wilt, Plantains, Seedless Bananas, Steve Savage

Almost all “dessert bananas” consumed in the U.S. are of one variety: the Cavendish. Dessert bananas are consumed raw, as opposed to “cooking bananas”, or plantains. This post by Steve Savage on his Applied Mythology blog provides some history of the commercial banana and the reasons why the market is dominated by a single banana cultivar. Many other cultivars exist across the globe, but there are sound economic reasons for the dominance of the Cavendish. For starters, people like them!

Incredibly, bananas became one of the early modern fruit staples, available at an affordable price at all times of the year, even in the dead of winter far from the hospitable growing conditions of the tropics. At that time, the dominant banana variety was the Gros Michel, but it fell victim to a fungus called Panama Wilt in the 1950s (still, populations of the Gros Michel survive today). The Cavendish proved to be an excellent replacement, though banana enthusiasts claim that it is inferior to the Gros Michel. Nevertheless, the Cavendish has reigned as the “top banana” in international commerce ever since. Now, however, the Cavendish is threatened by a relatively new strain of the same fungus that ravaged the Gros Michel. The impact so far has been felt mainly in Asia, but it is expected to spread.

This vulnerability has led to criticism of the industry’s reliance on the Cavendish as an example of “extreme monoculture”. Savage regards this as uninformed. He acknowledges the wide diversity of banana cultivars around the globe, but he asserts that the critics do not have a sound understanding of the highly-calibrated economics of growing, transporting, ripening and delivering bananas at the optimal point in the ripening process. The Cavendish meets the requirements of that process far better than the many other varieties, so its long-time dominance in export markets reflects rational decision-making:

“First of all, a banana for export has to be seedless. Many wild bananas have large, very hard black seeds – not something that has much consumer appeal. …“

By the way, seedless bananas (or rather, bananas with tiny, undeveloped seeds) are not GMOs, as the term is popularly understood. Domestication of the banana began several thousand years ago as early farmers selectively bred those plants producing the most desirable fruit for consumption: less seeds and more pulp. Savage goes on:

“Next, the banana needs to be productive in terms of overall yield per tree or acre. … The usable per-hectare yields of the Cavendish variety are quite high, and that is why it has been a both economically viable and environmentally sustainable choice for a long time. …

But probably the most limiting requirement for a banana variety to be commercially acceptable is that it has to be shippable. … Very few of the wonderful range of cultivated or wild banana types could ever do that, but because the Cavendish can be shipped this way, the energy and carbon footprint of its shipment is small. This crop has a very attractive ‘food-miles’ profile.“

In addition, Savage explains that the ripening process must be manageable and predictable. For all of these reasons, the Cavendish (and the Gros Michel in its time) has been an ideal choice in international commerce.

There are many potential solutions to the new challenge faced by the Cavendish, but they may or may not be able to provide a viable replacement before the new fungus presents a full-fledged crisis. You can learn about some of these alternatives at the Bananas.org forumoron other industry sites. For one thing, the Cavendish has shown to be protected from the fungus when grown in mixed plantations with papaya and coffee. In Taiwan, Cavendish bananas have been bred to resist the fungus. Other varieties are grown in central America and the Caribbean, including a surviving Gros Michel population, though it’s doubtful that it could survive the new fungus. There is also the so-called Apple Banana and the Berry Banana. While a greater variety of banana choices would be welcome to consumers, it is not clear how well these exotic bananas would meet the requirements of growers, shippers, grocers and consumers, and at a price that balances the interests of all parties.

There might also be a role for biotechnology in the effort to replace the Cavendish. Genetic engineering (GE) is a promising avenue through which disease-resistant varieties might be created, as it has with the papaya in Hawaii. It is also possible for GE to enhance the nutritional quality of crops. However, you can bet that food activists will condemn any attempt to leverage GE in banana farming.

The Gains From Traits: GMOs Bring Welfare Gains

08 Friday Jan 2016

Posted by Nuetzel in Biotechnology

≈ 1 Comment

Tags

Biology Fortified, Biotechnology, Conflict of Interest, crony capitalism, EU GMO Research, Facebook, GE Pharmaceuticals, genetic engineering, Genetic Food Progress, GMO Labelling, GMO Safety, GMO Skepti-Forum, GMOs, Industry-Funded Research, Insulin and GMOs, Julie Kelly, Libertarianism and GMOs, Marc Brazeau, Multi-Generational Studies, Robert Wenzel

GMO-Right Genes
For about 30 years I have injected analog human insulin, produced by GMO E. coli bacteria, directly into my tissue. And I feel great, as do many other Type I diabetics who benefit from the advance this offers over earlier insulins made with pork and beef insulin crystals. Quite simply, I have the wrong genes. Those bad genes enabled my immune system to destroy the insulin-producing cells I needed to stay alive. At first, that necessitated the use of a faulty substitute, but later, an organism was created in a lab with the right gene to produce the powerful analog insulin I use now.

There are many other genetically-engineered pharmaceutical products on the market today, and more are coming. Julie Kelly discusses some of these developments in “The March of Genetic Food Progress” (if gated, Google “wsj Julie Kelly Genetic”). One in particular is an egg laid by a GM chicken that treats:

“… a rare and potentially fatal disorder called lysosomal acid lipase deficiency. The chicken… produces eggs with an enzyme that replaces a faulty human enzyme, addressing the underlying cause of the disease.“

She also writes of GM piglets that resist a viral respiratory disease. Her article mentions a few promising new GMOs foods in the pipeline. In a Sacred Cow Chips post in July 2015, “Nice Splice: New & Old GMO Varieties Blossom“, I quoted William Saletan on a large number of new GMOs, which I repeat here:

“… drought-tolerant corn, virus-resistant plums, non-browning apples, potatoes with fewer natural toxins [and fewer carcinogens when fried], and soybeans that produce less saturated fat. … virus-resistant beans, heat-tolerant sugarcane, salt-tolerant wheat, disease-resistant cassava, high-iron rice, and cotton that requires less nitrogen fertilizer. … high-calcium carrots, antioxidant tomatoes, nonallergenic nuts, bacteria-resistant oranges, water-conserving wheat, corn and cassava loaded with extra nutrients, and a flaxlike plant that produces the healthy oil formerly available only in fish.“

GMO foods enhance farm productivity, reduce waste, conserve land, improve the environment and provide better nutrition. They offer solutions to a variety of human problems that are otherwise out-of-reach.

Anti-GMO activists have smeared all of these GMO crops and even GM insulin as unsafe, but they base their claims on shoddy “research” or willful misinterpretation of research. To scare-monger people with diseases like diabetes is repugnant. Decades of experience have proven the safety of modern insulin products. Those negative claims about insulin arose from a paper reviewed here, which had a different research purpose and did not even mention GMO-produced insulin.

GMOs have been in the food supply to some extent for over 25 years. There is no shortage of high-quality, independent, peer-reviewed research proving the safety of GMOs in various contexts, including multi-generational studies for GMO animal feeds. Here is a review of GMO safety and environmental research funded by the EU. Another review of 10 years of safety research found that:

“The scientific research conducted so far has not detected any significant hazards directly connected with the use of genetically engineered crops.”

An excellent post by Marc Brazeau on the Biology Fortified blog, “About Those Industry Funded GMO Studies“, covers a variety of research demonstrating GMO safety for humans, livestock, honey bees, and invertebrates. As the title suggests, Brazeau also probes the question of financial or professional conflict of interest, industry funding and their alleged impact on GMO research. Favorable GMO research is often condemned by activists on this basis. The “industry shill” argument is often invoked by activists to dismiss positive results regardless of the experimental rigor involved. Brazeau reviews some research on these questions, and notes the following:

“… where compositional studies are concerned … the company has already performed in-house studies. They are contracting independent scientists to confirm their findings. This is going to skew the results of the sample towards industry favorable study outcomes. This doesn’t mean the studies were suspect. They were just more likely to result in a favorable outcome to begin with. If the in-house study had an unfavorable outcome in compositional assessment or other tests, then that project would be stopped and it’s back to the drawing board for a new project. There is no need for follow up testing by outside independent researchers. That’s a big reason why so many studies … will produce favorable results.“

I highly recommend the GMO Skepti-Forum on Facebook as a site on which informed (and usually civil) debate takes place on GMOs. Many of the discussants are scientists actively involved in GMO research. It’s a go-to location for me when investigating on-line memes that reference GMO research.

Finally, Robert Wenzel posts some thoughts regarding “Libertarianism and GMOs“. His position on GMOs mirrors my own. He asserts that individuals have a choice about whether to consume GMOs; they are capable of finding alternatives without imposing restrictions the behavior of others who wish to avail themselves of the benefits or are unconcerned about alleged risks. In fact, the benefits often include affordability and safety. Wenzel argues that this position is consistent with the non-aggression principle, the philosophical anchor of Libertarianism.

Some libertarians object to Wenzel’s defense of biotechnology based on the crony capitalism that undoubtedly benefits the biotech industry, as well as his opposition to GMO labelling. There are certainly ties between the large biotech firms and regulators, but that is no reason to condemn the technology. Labelling proponents start from the faulty premise that there is something inherently harmful about consuming GMOs. Their solution is to impose costs on others, while they are already free to purchase their food from purveyors who offer non-GMO assurances. Hence, the argument that forced labelling represents a form of aggression.

 

Would Heterosexuals Select For Gay Genes?

26 Sunday Jul 2015

Posted by Nuetzel in Biotechnology, Progressivism

≈ 2 Comments

Tags

Abortion, Bruce Carroll, Dennis Sewell, Eugenics, Friedrich Hayek, Gay Gene, genetic screening, John Maynard Keynes, Jonathan Freedland, LGBT, Progressivism, The Gay Patriot, The Guardian, The Political Gene

Selection-conundrum-cartoon

Economic and social planning by the state can mean many things, but a planned society is always held in some form as a progressive goal. This is at the very heart of  “statism”. As Hayek noted, the fascination with planning is rooted in a belief that conscious, central direction is necessary in order for society to advance. This stands in stark contrast to the abysmal failure and monstrous cruelty of social planning historically, and the unmatched success of markets and a free, spontaneous social order at improving human welfare.

The faith in central direction has always been conjoined with a belief in the ability of scientific methods to address social issues. This line of thinking is flawed in many respects, but 80 to 100 years ago, an extremely perverse manifestation of this statist philosophy was a fascination with eugenics, or the intentional selection and rejection of various traits in offspring at the state’s direction. Sterilization of the “unfit”, and selective breeding of the most fit, were weirdly popular notions among progressives in that era. In 2012, Jonathan Freedland in The Guardian called eugenics “the skeleton that rattles loudest in the left’s closet”.

“Most alarming, many of its leading advocates were found among the luminaries of the Fabian and socialist left, men and women revered to this day. Thus George Bernard Shaw could insist that ‘the only fundamental and possible socialism is the socialisation of the selective breeding of man’, even suggesting, in a phrase that chills the blood, that defectives be dealt with by means of a ‘lethal chamber’. …

According to Dennis Sewell, whose book The Political Gene charts the impact of Darwinian ideas on politics, the eugenics movement’s definition of ‘unfit’ was not limited to the physically or mentally impaired. It held, he writes, ‘that most of the behavioural traits that led to poverty were inherited. In short, that the poor were genetically inferior to the educated middle class.’ It was not poverty that had to be reduced or even eliminated: it was the poor.

Hence the enthusiasm of John Maynard Keynes, director of the Eugenics Society from 1937 to 1944, for contraception, essential because the working class was too ‘drunken and ignorant’ to keep its numbers down.“

This post on the historical allure of eugenics to progressives is also informative. Of course, the National Socialists in Germany took the idea and ran with it, which ultimately led to a rejection of eugenics in the West. Yet the idea lives on today through various mechanisms, such as sex-selective abortion and screening for certain genetic disorders. Of course there is a widespread insistence on abortion as a “woman’s right” on the progressive left, but certain questions are seldom asked. For example, does that include women who wish not to bear children with disorders such as Down’s Syndrome? There is less unanimity on that issue.

Bruce Carroll, aka, The Gay Patriot, asks a different question: “What Happens When Science Allows Us to Abort A Baby If It Has the ‘Gay Gene’?” The mapping of the human genome has advanced to the point that it might be possible to identify the precise genetics determining certain social and personality characteristics. There is some research suggesting that regions on two different chromosomes might allow geneticists to home-in on the identification of specific “gay genes”.

The first question this raises is whether a woman (or a couple) has the right to know everything predicted about a child from its pre-natal genetic testing. I assume that all test results are private. Should the information about sexual-preference genes be off-limits to a parent? Information about gender is not off-limits, and you can be certain that even in the U.S., an occasional woman or couple decides to terminate a pregnancy for reasons of gender, whatever the motive. If the sexual preference genes are off-limits, then the inescapable conclusion is that sexual preference is “protected” in the womb by society, but gender and a whole range of disabilities are not protected. Really? Carroll takes a dim view of the LGBT politics on this matter:

“I wonder if gay activists realize that their slobbering devotion to pro-abortion political organizations, and the multi-million dollar abortion industry itself, may ultimately lead to the destruction of LGBT babies before they are born within my lifetime. It truly is Sophie’s Choice for the progressive gay activists; thus far, they wave off the question with derision.“

The question can be put in less drastic terms, if genetic selection can really ever be less drastic. Technologies to create “designer babies” through genetic selection are already here. That implies both positive selection and deselection of various traits. Obviously, this is not a simple subject from a either a scientific or ethical standpoint, but to zero in on our hypothetical question, I assume for now, for the sake of argument, that parents are legally empowered “to give their children the best start possible“. That would be the “best start” in the parents’ opinion, not the state’s! One wonders how the LGBT community, and the Left in general, would react to a service allowing couples, or a mother, to select for heterosexual genes in their “designer offspring”, consequently selecting against gay genes. Should such options be “off the table” as a matter of public policy? But again, if so, then what about gender? What about disabilities?

Involving the state in these decisions will lead to either bizarre contradictions or restrictions on autonomy that both Left and Right might find unacceptable.

Nice Splice: New & Old GMO Varieties Blossom

16 Thursday Jul 2015

Posted by Nuetzel in Biotechnology

≈ 1 Comment

Tags

Bill Nye the Science Guy, Bt gene, Dan Charles, David Wolfe, GE food., genetic engineering, genetic modification, Glyphosate, GMO food, golden Rice, herbicide resistance, Lydia Ramsey, Monsanto, NPR, Ringspot virus, Roundup Ready, Slate, William Saletan

image

Good for Bill Nye the Science Guy! And separately, good for Slate! First, the pop “scientist” Nye has turned the corner and now understands that genetic engineering (GE) and genetically modified organisms (GMOs) represent wonderful technology, holding great promise for humanity. Here is what he describes as the key:

“This is what changed my mind, is being able to do [sequence genes] 10 million times faster than they used to be able to do it … and being able to eliminate the ones not suitable for farming and susceptible to diseases and so on. We’re farmers, and we want them to come out the way we want them.“

Lydia Ramsey, whose post at Business Insider is linked above, distills Nye’s position this way:

“We are a society of farmers, and for thousands of years, farmers have been doing everything in their power to get the most product from their labor. Genetically modified crops are a way to do that.“

Apparently Nye is also impressed with the lengthy selection process and careful testing  that takes place before GMOs are ever brought to market. That contrasts with the nonexistent testing that is typical of conventional cross-breeding and irradiation, which can result in millions of gene mutations.

Nye, a mechanical engineer by training, probably knows enough science to recognize that there is a massive volume of literature that testifies to the safety of GMO crops (see here and here).

In Slate, William Saletan has written an excellent report entitled “Unhealthy Fixation“, and subtitled “The war against genetically modified organisms is full of fearmongering, errors, and fraud. Labeling them will not make you safer.”  Saletan emphasizes that GE is not any one single “thing”, but instead is a process. He discusses the histories of four distinct GMO issues:

  1. Overcoming the devastation of the papaya ringspot virus;
  2. Crops with a single Bt gene inserted versus Bt insecticides used on organics;
  3. Malnutrition, childhood blindness, and Golden Rice;
  4. Herbicide tolerance, farm productivity and herbicide overuse;

The fourth issue is an unfortunate aspect of our experience with GMOs, even to this day: much of it has related to strains of GE crops that are resistant to herbicides, glyphosate being the most prominent (until the patent expired in 2000, Monsanto’s Roundup was the only brand). In the public imagination, GMOs are almost synonymous with “Roundup-ready” crops. Glyphosate is only one type of herbicide, however, and there are significant benefits to herbicide-resistant crops, some of which are created without the help of GE. But herbicide-resistant crops are only one type of GMO. There are many other GMO varieties, and Saletan provides a long list of varieties in the pipeline:

“… drought-tolerant corn, virus-resistant plums, non-browning apples, potatoes with fewer natural toxins [and fewer carcinogens when fried], and soybeans that produce less saturated fat. … virus-resistant beans, heat-tolerant sugarcane, salt-tolerant wheat, disease-resistant cassava, high-iron rice, and cotton that requires less nitrogen fertilizer. … high-calcium carrots, antioxidant tomatoes, nonallergenic nuts, bacteria-resistant oranges, water-conserving wheat, corn and cassava loaded with extra nutrients, and a flaxlike plant that produces the healthy oil formerly available only in fish.“

Saletan bemoans the dominance of the herbicide industry in commercial applications of GMOs. He wants the food industry and regulators to move forward with the many other promising GE applications like those listed in the quote above. He also rightly blames anti-GMO activists for holding up promising varieties:

“First, it’s true that the issue is complicated. But the deeper you dig, the more fraud you find in the case against GMOs. It’s full of errors, fallacies, misconceptions, misrepresentations, and lies. The people who tell you that Monsanto is hiding the truth are themselves hiding evidence that their own allegations about GMOs are false. They’re counting on you to feel overwhelmed by the science and to accept, as a gut presumption, their message of distrust.“

There is a lot about GE technology for farmers and consumers to love. Many detractors seem unaware that life-saving products like insulin are made with GMOs, or that GMOs are in widespread use in the production of products like cheese, beer, and wine. The anti-GMO drumbeat goes on, however, promoting myths like the five discussed here by Dan Charles at NPR. This includes the fallacy that farmers saved their own seeds for planting until Monsanto came along. A particularly egregious piece of recent propaganda was a video promoted by the huckster David Wolfe. It involved a family who ate only organic food for two weeks and saw the trace levels of pesticides in their urine vanish. Of course, the researchers did not test for organic pesticides, such as Bt, but that escapes the notice of Wolfe’s uncritical acolytes.

You’ll find eight earlier posts related to GMOs on Sacred Cow Chips at this link.

Haunted By Food Demons

03 Wednesday Jun 2015

Posted by Nuetzel in Biotechnology

≈ Leave a comment

Tags

GE crops, Glyphosate, GMOs, Herbicides, Pesticides, Roundup, The Credible Hulk, Toxicity

dr-jekyll gmo Glyphosate herbicide usage (as in Roundup) in the U.S. has increased dramatically over the last two decades, replacing the use of far more toxic herbicides on many crops. That’s one of the major points in a post at The Credible Hulk blog entitled “About those more caustic herbicides that glyphosate helped replace“. The increased use of glyphosate corresponded to heavier reliance on glyphosate-tolerant strains of genetically-engineered crops. The author provides charts and other details on the changing use of a number of different herbicides both over time and across crop varieties.

“… the purpose of this [post] is to show that when opponents of GE technology and of glyphosate claim that GR crops are bad on the grounds that they increased glyphosate use, they are leaving out critical information that would be highly inconvenient for their narrative.“

The use of insect-resistant GE crops has also been associated with a declines in total pesticide use. [The links above are all given in The Credible Hulk post].

There is a great deal of distortion prompted by certain interest groups who oppose the use of synthetic herbicides and insecticides and GMOs. Irrational fears among consumers are inflamed by this sort of propaganda. This post and this post give farmers’ perspectives on some of the misinformation with respect to glyphosate. No, farmer’s do not “drench” their crops with glyphosate prior to harvest. That claim is pure hyperbole.

It’s also important to note that organic crops are not free of treatments. So-called organic pesticides are often just as toxic as synthetic pesticides, and they are often used in heavier quantities. Furthermore, organic foods carry undeniable health risks to consumers. A balanced view must acknowledge the benefits of crop treatments to consumers (whether the treatments are organic or nonorganic), that residues on produce in the U.S. are minimal, that safety still dictates that consumers wash their produce, and that consumers deserve a free choice between crops grown conventionally or organically.

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