Junk Science Malignancy

07 Thursday Apr 2016

Posted by pnoetx in genetic engineering, Technology

Tags

Andrew Porterfield, Animal Feeding Studies, Donald Danforth Plant Science Center, genetic engineering, Genetic Literacy Project, genetic modification, Gilles-Eric Séralini, Glyphosate Resistance, GMOs, Junk Science, Kevin Folta, Peer Review, Plant Science, Roundup Pesticide, Séralini Affair

A retracted 2012 study purporting to show that genetically modified (GMO) corn causes cancer was not recently vindicated by French courts. A few publications lacking minimal journalistic standards have made that false claim. There was a favorable ruling in a libel suit brought by Gilles-Eric Séralini, author of the study, but it did not vindicate his sloppy research in any way. The court simply agreed that the defendant could not prove that Séralini had committed fraud. In the U.S., proof of malice by the defendant would have been required for a libel verdict, but not in France. In any case, the ruling did not address the scientific validity of Séralini’s research, only that it was not willfully fraudulent. Courts do not serve as arbiters of scientific validity.

The study itself was awful. Details can be found here. Séralini used rats that were bred to develop cancer with an extremely high incidence (70% – 80% lifetime); he tested different groups of these rats with varying amounts of GMO corn and Roundup pesticide. The small samples he used meant that the tests had very low statistical power. There were suspicious aspects of the study that might or might not have been cleared up with sufficient disclosure, and there was even contradictory evidence within the study itself, as would be expected with so much statistical noise. Séralini’s efforts to publicize the paper didn’t help his reputation in the scientific community. He made some exaggerated claims, and though he might have believed them, he was clearly interested in making a big splash.

The paper received overwhelming criticism in the scientific community. It was retracted by the journal that originally published it, but later it was republished in a low-quality journal without peer review. This study was not the first piece of Séralini research to be harshly criticized by his peers. Here are comments from the blog of respected horticulturist Kevin Folta, who does not mince words:

“It boils down to this– if these data were significant, if the experiments were good, and the interpretations sound, this would not be buried in the depths of a crappy journal. If there was hard evidence that our food supply truly caused tumors, it would be on the New England Journal of Medicine, Science, Nature, or maybe Cell if he wanted to go slumming. But it’s not there. It is in a tiny, obscure journal that has quite a visible agenda, and that’s the only thing visible about it.

And that’s where it belongs. Let him have his day in the sun. History will not remember him for his science. It will remember him as a disgraceful hack that let personal agenda affect adoption of safe scientific technology. He’ll be the guy that fooled millions with low-quality data.

It is very sad, because I’d rather be writing blogs about exciting science and new findings. Instead we’re back to this nonsense. Luckily, it will slowly disappear into time, like Puzstai’s lectins, Huber’s mystery organism, and the rest of the alarmist junk never published or never reproduced.“

An issue that has been thorny for GMO advocates is the erroneous conflation of GMOs with glyphosate (Roundup is one brand). Séralini’s work focused on glyphosate-resistant GMOs, and his treatments involved the administration of glyphosate to rats in varying quantities, but publicity surrounding the study gave the impression that his “findings” applied more generally to GMOs. Glyphosate resistant plants were an early product of the GMO technology, but most GMO plants have nothing to do with glyphosate. Instead, they confer benefits such as nutritional superiority, drought resistance, pest resistance, disease resistance, and improved environmental consequences of agriculture. The variety of problems that can be addressed with GMOs is staggering.

The safety of GMOs is well established in the plant science literature. Use the box above to search Sacred Cow Chips for “GMO” or “genetic” to find earlier posts in which I have addressed GMO safety at greater length. A recent article from Andrew Porterfield of the Genetic Literacy Project addresses some aspects of this literature and on long-term animal feeding studies, which have demonstrated the safety of GMOs.

A petition in support of GMO technology signed by over 1,400 plant science experts is linked in this article in Science Daily. Three of the authors of the petition are affiliated with The Donald Danforth Plant Science Center in Creve Coeur, Missouri, not far from my home. The petition vouches for the safety of GMOs and their promise in meeting the world’s demand for food.

Note: the infographic at the top of this post is from the Biology Fortified blog.

Nice Splice: New & Old GMO Varieties Blossom

16 Thursday Jul 2015

Posted by pnoetx in Biotechnology

≈ 1 Comment

Tags

Bill Nye the Science Guy, Bt gene, Dan Charles, David Wolfe, GE food., genetic engineering, genetic modification, Glyphosate, GMO food, golden Rice, herbicide resistance, Lydia Ramsey, Monsanto, NPR, Ringspot virus, Roundup Ready, Slate, William Saletan

Good for Bill Nye the Science Guy! And separately, good for Slate! First, the pop “scientist” Nye has turned the corner and now understands that genetic engineering (GE) and genetically modified organisms (GMOs) represent wonderful technology, holding great promise for humanity. Here is what he describes as the key:

“This is what changed my mind, is being able to do [sequence genes] 10 million times faster than they used to be able to do it … and being able to eliminate the ones not suitable for farming and susceptible to diseases and so on. We’re farmers, and we want them to come out the way we want them.“

Lydia Ramsey, whose post at Business Insider is linked above, distills Nye’s position this way:

“We are a society of farmers, and for thousands of years, farmers have been doing everything in their power to get the most product from their labor. Genetically modified crops are a way to do that.“

Apparently Nye is also impressed with the lengthy selection process and careful testing that takes place before GMOs are ever brought to market. That contrasts with the nonexistent testing that is typical of conventional cross-breeding and irradiation, which can result in millions of gene mutations.

Nye, a mechanical engineer by training, probably knows enough science to recognize that there is a massive volume of literature that testifies to the safety of GMO crops (see here and here).

In Slate, William Saletan has written an excellent report entitled “Unhealthy Fixation“, and subtitled “The war against genetically modified organisms is full of fearmongering, errors, and fraud. Labeling them will not make you safer.” Saletan emphasizes that GE is not any one single “thing”, but instead is a process. He discusses the histories of four distinct GMO issues:

Overcoming the devastation of the papaya ringspot virus;
Crops with a single Bt gene inserted versus Bt insecticides used on organics;
Malnutrition, childhood blindness, and Golden Rice;
Herbicide tolerance, farm productivity and herbicide overuse;

The fourth issue is an unfortunate aspect of our experience with GMOs, even to this day: much of it has related to strains of GE crops that are resistant to herbicides, glyphosate being the most prominent (until the patent expired in 2000, Monsanto’s Roundup was the only brand). In the public imagination, GMOs are almost synonymous with “Roundup-ready” crops. Glyphosate is only one type of herbicide, however, and there are significant benefits to herbicide-resistant crops, some of which are created without the help of GE. But herbicide-resistant crops are only one type of GMO. There are many other GMO varieties, and Saletan provides a long list of varieties in the pipeline:

“… drought-tolerant corn, virus-resistant plums, non-browning apples, potatoes with fewer natural toxins [and fewer carcinogens when fried], and soybeans that produce less saturated fat. … virus-resistant beans, heat-tolerant sugarcane, salt-tolerant wheat, disease-resistant cassava, high-iron rice, and cotton that requires less nitrogen fertilizer. … high-calcium carrots, antioxidant tomatoes, nonallergenic nuts, bacteria-resistant oranges, water-conserving wheat, corn and cassava loaded with extra nutrients, and a flaxlike plant that produces the healthy oil formerly available only in fish.“

Saletan bemoans the dominance of the herbicide industry in commercial applications of GMOs. He wants the food industry and regulators to move forward with the many other promising GE applications like those listed in the quote above. He also rightly blames anti-GMO activists for holding up promising varieties:

“First, it’s true that the issue is complicated. But the deeper you dig, the more fraud you find in the case against GMOs. It’s full of errors, fallacies, misconceptions, misrepresentations, and lies. The people who tell you that Monsanto is hiding the truth are themselves hiding evidence that their own allegations about GMOs are false. They’re counting on you to feel overwhelmed by the science and to accept, as a gut presumption, their message of distrust.“

There is a lot about GE technology for farmers and consumers to love. Many detractors seem unaware that life-saving products like insulin are made with GMOs, or that GMOs are in widespread use in the production of products like cheese, beer, and wine. The anti-GMO drumbeat goes on, however, promoting myths like the five discussed here by Dan Charles at NPR. This includes the fallacy that farmers saved their own seeds for planting until Monsanto came along. A particularly egregious piece of recent propaganda was a video promoted by the huckster David Wolfe. It involved a family who ate only organic food for two weeks and saw the trace levels of pesticides in their urine vanish. Of course, the researchers did not test for organic pesticides, such as Bt, but that escapes the notice of Wolfe’s uncritical acolytes.

You’ll find eight earlier posts related to GMOs on Sacred Cow Chips at this link.

Don’t Mind Eating GMOs, But Sure Love Injecting Them

04 Saturday Oct 2014

Posted by pnoetx in Uncategorized

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Tags

Biotechnology, Bt, Chinese GMOs, ebola, genetic modification, GMOs, insulin, Leukemia, Luddites, Serelini

I have relied upon injections of genetically modified insulin hormone to keep me alive for many years. The benefits of biotechnology for mankind are supported by decades of hard experience and volumes of careful research, and there is no evidence of harm. But that can’t dissuade neo-Luddites in their efforts to foment panicked opposition to genetic modification of crops.

Another GMO horror story has been circulating about an experiment said to have been conducted at a Chinese university in which students were fed Bt rice. The claim is that an outbreak of acute leukemia ensued. This report bears all the all the earmarks of a fraud, right down to the fact that no one on campus seems to have heard about it!

Anti-GMO activists disparage critics for calling attention to the “fringe” character of the outlets promoting their views, or by diminishing opposing claims as “corporate,” when in fact the real problems are that those activists rely on badly designed and executed research and superstitions about technology. Articles about the alleged Chinese GMO experiment make false claims about prior research findings of a link between GMOs and leukemia. In fact, while the authors of that earlier research don’t admit it, their work casts more doubt on the safety of organic Bt pesticides than on GM crops expressing the Bt toxin. In other words, it’s lousy research. See here for further confirmation. This is reminiscent of other flimsy research promoted by the anti-GMO lobby, such as the notoriously bad Serelini study that used, as subjects, rats that had been bred to develop tumors.

Oddly, hysteria over GM crops does not extend to the genetically modified antibodies created to cure diseases like ebola. Synthetic human insulin is made via genetic modification too! Why no opposition? Perhaps because the activists recognize the impressive benefits of the biotechnology in this context. The potential benefits of GM crops are no less impressive. And despite the best efforts of the anti-GMO lobby, there is no persuasive evidence that GM foods are harmful.